abstract：:The current study examined the factor structure of the Brief Negative Symptom Scale (BNSS), a next-generation negative symptom rating instrument developed in response to the NIMH-sponsored Consensus Development Conference on Negative Symptoms. Participants included 146 individuals with a DSM-IV diagnosis of schizophre...

journal_title：Schizophrenia research

authors： Strauss GP,Hong LE,Gold JM,Buchanan RW,McMahon RP,Keller WR,Fischer BA,Catalano LT,Culbreth AJ,Carpenter WT,Kirkpatrick B

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Recent research has identified impairment in processing speed, measured by the digit-symbol substitution task, as central to the cognitive deficit in schizophrenia. However, the underlying cognitive correlates of this impairment remain unknown. METHODS:A sample of cases (N=125) meeting DSM-IV criteria for s...

journal_title：Schizophrenia research

authors： Knowles EE,Weiser M,David AS,Dickinson D,Glahn D,Gold J,Davidson M,Reichenberg A

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Despite the upsurge of research regarding cognitive impairment in schizophrenia we still lack adequate understanding of the executive functioning of patients in symptomatic remission. Moreover, the cognitive functioning of patients in partial remission has not been studied previously although they comprise a...

journal_title：Schizophrenia research

authors： Braw Y,Benozio A,Levkovitz Y

更新日期：2012-12-01 00:00:00

abstract：:The minor neurological and cognitive deficits consistently reported in psychoses may reflect the same underlying brain dysfunction. Still, even in healthy individuals minor neurological abnormalities are associated with worse cognitive function. Therefore, establishing which neurological and cognitive deficits are spe...

journal_title：Schizophrenia research

authors： Mellacqua Z,Eyeson J,Orr KD,Morgan KD,Zanelli J,Lloyd T,Morgan C,Fearon P,Hutchinson G,Doody GA,Chan RC,Harrison G,Jones PB,Murray RM,Reichenberg A,Dazzan P

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Targeting glutamatergic dysfunction provides an exciting opportunity to improve cognitive impairment in schizophrenia. One treatment approach has targeted inadequate antioxidant defenses at glutamatergic synapses. Animal and human data suggest NMDA antagonists worsen executive cognitive controls--e.g. increa...

journal_title：Schizophrenia research

authors： Chengappa KN,Turkin SR,DeSanti S,Bowie CR,Brar JS,Schlicht PJ,Murphy SL,Hetrick ML,Bilder R,Fleet D

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:A small but significant association between schizophrenia and violence is open to a number of explanations. Impaired empathy has been associated with schizophrenia, and with violence in the general population. Our aim was to conduct a systematic review of any research into relationships between schizophrenia...

journal_title：Schizophrenia research

authors： Bragado-Jimenez MD,Taylor PJ

更新日期：2012-10-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNAs that mainly function as negative regulators of gene expression (Lai, 2002) and have been shown to be involved in schizophrenia etiology through genetic and expression studies (Burmistrova et al., 2007; Hansen et al., 2007a; Perkins et al., 2007; Beveridge et al., 2010; Kim ...

journal_title：Schizophrenia research

authors： Kim AH,Parker EK,Williamson V,McMichael GO,Fanous AH,Vladimirov VI

更新日期：2012-10-01 00:00:00

abstract：:Individuals with 22q11.2 deletion syndrome (22q11.2DS) evince a 30% incidence of schizophrenia. We compared the white matter (WM) of 22q11.2DS patients without schizophrenia to a group of matched healthy controls using Tract-Based-Spatial-Statistics (TBSS). We found localized reduction of Fractional Anisotropy (FA) an...

journal_title：Schizophrenia research

authors： Kikinis Z,Asami T,Bouix S,Finn CT,Ballinger T,Tworog-Dube E,Kucherlapati R,Kikinis R,Shenton ME,Kubicki M

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Higher cognitive dysfunction, lower perceptual disturbance and its relation to the structures that implicate such processes have been considered as key features in patients with schizophrenia. However, little is known about the relationship between perceptual processing and structural deficits in ultra-high-...

journal_title：Schizophrenia research

authors： Shin KS,Jung WH,Kim JS,Jang JH,Hwang JY,Chung CK,Kwon JS

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVE:This study aims to differentiate schizoaffective disorder (SAD) and bipolar-I-disorder (BD) in first-episode psychotic mania (FEPM). METHODS:All 134 patients from an epidemiological first-episode psychosis cohort (N=786) with FEPM and an 18-month follow-up final diagnosis of SAD (n=36) or BD (n=98) were asse...

journal_title：Schizophrenia research

authors： Schöttle D,Schimmelmann BG,Conus P,Cotton SM,Michel C,McGorry PD,Karow A,Naber D,Lambert M

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Evidence indicating that symptoms of non-clinical psychosis (NCP) occur in 6-8% of the general population suggests that psychosis may occur across a continuum. Although a number of studies have examined environmental contributors, to date there have been few investigations of biological/genetic factors in th...

journal_title：Schizophrenia research

authors： Mittal VA,Smolen A,Dean DJ,Pelletier AL,Lunsford-Avery J,Smith A

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Psychotic-like experiences (PLEs) during adolescence are not uncommon and potentially represent a clinical and public health concern. A greater understanding of their aetiology and patterns of change over time is needed. We aimed to describe trajectories of PLEs during adolescence, and examine their associat...

journal_title：Schizophrenia research

authors： Thapar A,Heron J,Jones RB,Owen MJ,Lewis G,Zammit S

更新日期：2012-09-01 00:00:00

abstract：:There is growing awareness that reduced expressive behaviors (e.g., blunt affect, alogia, psychomotor retardation) are characteristic of a range of psychiatric conditions, including mood and schizophrenia-spectrum disorders. From a Research Domain Criteria (RDoC) perspective, it would be critical to determine whether ...

journal_title：Schizophrenia research

authors： Cohen AS,Najolia GM,Kim Y,Dinzeo TJ

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVE:Suicide is the leading cause of death in schizophrenia. An association between suicidal behavior and both higher and lower cognitive ability in schizophrenia has been reported. To clarify this relationship, we investigated whether the relationship between suicidality and neurocognition varied according to dif...

journal_title：Schizophrenia research

authors： Delaney C,McGrane J,Cummings E,Morris DW,Tropea D,Gill M,Corvin A,Donohoe G

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Neurological soft signs (NSS) are intrinsic features of psychosis that appear years before beginning a drug treatment. However, whether NSS respond to antipsychotics and whether these changes are clinically reliable and significant remains to be seen. OBJECTIVE:We sought to determine the effect of antipsych...

journal_title：Schizophrenia research

authors： Cuesta MJ,Campos MS,García-Jalón E,Sánchez-Torres AM,Peralta V

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVES:This nation-wide register-based study investigates the family load of schizophrenia (SZ) across three generations in affected families compared to control families. Furthermore the study compares the family load in case vs. control families considering the age of onset of the disorder in the cases. In additi...

journal_title：Schizophrenia research

authors： Helenius D,Munk-Jørgensen P,Steinhausen HC

更新日期：2012-08-01 00:00:00

abstract：:A recent single-site study (Fisher et al., 2009. Am J Psychiatry. 166 (7) 805-11) showed that repeated training with the Brain Fitness Program (BFP) improved performance on a battery of neuropsychological tasks. If replicated these data suggest an important non-pharmacological method for ameliorating cognitive impairm...

journal_title：Schizophrenia research

authors： Murthy NV,Mahncke H,Wexler BE,Maruff P,Inamdar A,Zucchetto M,Lund J,Shabbir S,Shergill S,Keshavan M,Kapur S,Laruelle M,Alexander R

更新日期：2012-08-01 00:00:00

abstract：:Despite the notion that increases in functioning should be associated with increases in life satisfaction in schizophrenia, research has often found no association between the two. Dual change models of global and domain-specific life satisfaction and functioning were examined in 145 individuals with schizophrenia rec...

journal_title：Schizophrenia research

authors： Edmondson M,Pahwa R,Lee KK,Hoe M,Brekke JS

更新日期：2012-08-01 00:00:00

abstract：:Up to 50-90% of persons with schizophrenia smoke cigarettes. Limited data and theories suggest persons with schizophrenia may smoke for different reasons than persons without schizophrenia, making smoking cessation interventions particularly challenging in this population. Although health consequences of smoking are w...

journal_title：Schizophrenia research

authors： Wehring HJ,Liu F,McMahon RP,Mackowick KM,Love RC,Dixon L,Kelly DL

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:Childhood and adolescence represent the periods during which hallucinatory experiences occur at the greatest prevalence, and also constitute a critical window of vulnerability for the pathogenesis of psychotic disorders. The longitudinal course of hallucinatory experiences during late childhood and adolescen...

journal_title：Schizophrenia research

authors： Rubio JM,Sanjuán J,Flórez-Salamanca L,Cuesta MJ

更新日期：2012-07-01 00:00:00

abstract：OBJECTIVE:Following encouraging results in the early detection of psychotic disorders, interest in the early detection of affective, especially bipolar disorders, has recently been renewed. However, the differentiation between affective disorders with and without psychotic features is often missing, although it has bee...

journal_title：Schizophrenia research

authors： Schultze-Lutter F,Schimmelmann BG,Klosterkötter J,Ruhrmann S

更新日期：2012-07-01 00:00:00

abstract：:Family members of first-episode psychosis (FEP) patients are regarded as key components of the patient's evaluation, recovery and treatment. This paper aimed to investigate 75 FEP caregivers' appraisal, psychological morbidity and quality of life in the initial phase of treatment in a specialized FEP outpatient progra...

journal_title：Schizophrenia research

authors： Jorge Rde C,Chaves AC

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:Cognitive remediation (CRT) affects functioning but the extent and type of cognitive improvements necessary are unknown. AIM:To develop and test models of how cognitive improvement transfers to work behaviour using the data from a current service. METHOD:Participants (N49) with a support worker and a paid ...

journal_title：Schizophrenia research

authors： Wykes T,Reeder C,Huddy V,Taylor R,Wood H,Ghirasim N,Kontis D,Landau S

更新日期：2012-06-01 00:00:00

abstract：OBJECTIVE:To assess the prevalence and correlates of antipsychotic polypharmacy (APP) across decades and regions. METHODS:Electronic PubMed/Google Scholar search for studies reporting on APP, published from 1970 to 05/2009. Median rates and interquartile ranges (IQR) were calculated and compared using non-parametric t...

journal_title：Schizophrenia research

authors： Gallego JA,Bonetti J,Zhang J,Kane JM,Correll CU

更新日期：2012-06-01 00:00:00

abstract：:Schizophrenia is associated with poor quality of life (QOL). Whereas the effects of neurocognitive deficits and psychopathology on QOL of schizophrenia patients have recently been elucidated, little is known about social cognitive deficits in this regard. This study investigated the influence of social cognition on QO...

journal_title：Schizophrenia research

authors： Maat A,Fett AK,Derks E,GROUP Investigators.

更新日期：2012-05-01 00:00:00

abstract：INTRODUCTION:Emotion perception (EP) is impaired in schizophrenia, is stable across clinical state, resistant to antipsychotic treatment and linked to symptom severity. Given its pervasive nature, there is a need to quantitatively examine whether this dysfunction impacts functional outcomes. We used a meta-analytic str...

journal_title：Schizophrenia research

authors： Irani F,Seligman S,Kamath V,Kohler C,Gur RC

更新日期：2012-05-01 00:00:00

abstract：:Synapsin II is a synaptic vesicle-associated phosphoprotein that has been implicated in the pathophysiology of schizophrenia. Researchers have demonstrated reductions in synapsin II mRNA and protein in post-mortem prefrontal cortex and hippocampus samples from patients with schizophrenia. Synapsin II protein expressio...

journal_title：Schizophrenia research

authors： Dyck BA,Tan ML,Daya RP,Basu D,Sookram CD,Thomas N,Mishra RK

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Prenatal micronutrient deficiency has been linked to later development of schizophrenia among offspring; however, no study has specifically investigated the association between vitamin A and this disorder. Vitamin A is an essential nutrient which is required by the early embryo and fetus for gene expression ...

journal_title：Schizophrenia research

authors： Bao Y,Ibram G,Blaner WS,Quesenberry CP,Shen L,McKeague IW,Schaefer CA,Susser ES,Brown AS

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVE:To investigate the relationship between the four-facet model of PCL-R psychopathy and violence in a community-based sample of Australian men with schizophrenia-spectrum disorders. METHOD:A community sample of 94 males with schizophrenia-spectrum disorders was recruited from mental health services within Vict...

journal_title：Schizophrenia research

authors： McGregor K,Castle D,Dolan M

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Findings from the WHO sponsored multicenter studies done a few decades ago, which reported favorable outcome of schizophrenia in developing countries both in 2 and 5 year follow-up studies, dominated the world view until recently. Emerging evidence from Low and Middle Income countries (LAMIC) started to chal...

journal_title：Schizophrenia research

authors： Teferra S,Shibre T,Fekadu A,Medhin G,Wakwoya A,Alem A,Jacobsson L

更新日期：2012-04-01 00:00:00

abstract：:A growing body of evidence suggests that abnormal elements of the cytoskeleton may be associated with the pathophysiology of schizophrenia. Isoforms of a major cytoskeleton protein, β-tubulin, were recently demonstrated to have distinct roles in neuronal differentiation and cell viability. For these reasons, we tested...

journal_title：Schizophrenia research

authors： Moehle MS,Luduena RF,Haroutunian V,Meador-Woodruff JH,McCullumsmith RE

更新日期：2012-03-01 00:00:00

abstract：:Though negative symptoms in schizophrenia are associated with a host of deleterious outcomes (e.g., White et al., 2009), not all individuals with schizophrenia suffer from negative symptoms (e.g., Blanchard et al., 2005). Thus, methods to quickly screen and identify patients for more intensive clinical interview asses...

journal_title：Schizophrenia research

authors： Park SG,Llerena K,McCarthy JM,Couture SM,Bennett ME,Blanchard JJ

更新日期：2012-03-01 00:00:00

abstract：:Numerous studies indicate that social dysfunction is associated with negative symptoms of schizophrenia during the chronic phase of illness. However, it is unclear whether social abnormalities exist during the premorbid phase in people who later develop schizophrenia with prominent negative symptoms, or whether social...

journal_title：Schizophrenia research

authors： Strauss GP,Allen DN,Miski P,Buchanan RW,Kirkpatrick B,Carpenter WT Jr

更新日期：2012-03-01 00:00:00

abstract：OBJECTIVE:Supported employment is the evidence-based treatment of choice for assisting individuals with severe mental illness to achieve competitive employment, but few supported employment programs specifically target older clients with psychiatric illness. The purpose of this study was to evaluate the efficacy of sup...

journal_title：Schizophrenia research

authors： Twamley EW,Vella L,Burton CZ,Becker DR,Bell MD,Jeste DV

更新日期：2012-03-01 00:00:00

abstract：:Learning and memory impairments are present in schizophrenia (SZ) throughout the illness course and predict psychosocial function. Abnormalities in prefrontal and hippocampal function are thought to contribute to SZ deficits. The radial arm maze (RAM) is a test of spatial learning and memory in rodents that relies on ...

journal_title：Schizophrenia research

authors： Spieker EA,Astur RS,West JT,Griego JA,Rowland LM

更新日期：2012-03-01 00:00:00

abstract：:Schizophrenia impairs both facial emotion processing and sustained attention. Through separate studies, it is known that the presence of a task-irrelevant facial stimulus disproportionately interferes with performance, whereas increasing the salience of task stimulus improves performance during a sustained attention t...

journal_title：Schizophrenia research

authors： Park SH,Noh JC,Kim JH,Lee J,Park JY,Lee YR,Kim CH,Lee KH

更新日期：2012-03-01 00:00:00

abstract：:Poor insight into the neurocognitive deficits in schizophrenia-spectrum disorders may have significant clinical implications for treatment. The purpose of this study was to replicate and extend the psychometric findings initially reported on the Measure of Insight into Cognition Clinician-Rated (MIC-CR) and Self-Repor...

journal_title：Schizophrenia research

authors： Saperstein AM,Thysen J,Medalia A

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Previous studies have found increased prolactin concentrations in antipsychotic-naïve patients with schizophrenia. However, the roles of other hormones, and of potentially confounding variables such as gender and smoking, have not been considered. METHODS:Blood from newly diagnosed, antipsychotic-naïve pati...

journal_title：Schizophrenia research

authors： Garcia-Rizo C,Fernandez-Egea E,Oliveira C,Justicia A,Parellada E,Bernardo M,Kirkpatrick B

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Negative symptoms are a core feature of schizophrenia. The evolution and trajectory of primary negative symptoms were under-studied. We aimed at evaluating the prevalence and stability of primary negative symptoms, and factors associated with persistent primary negative symptoms in a first-episode sample. M...

journal_title：Schizophrenia research

authors： Chang WC,Hui CL,Tang JY,Wong GH,Lam MM,Chan SK,Chen EY

更新日期：2011-12-01 00:00:00

abstract：OBJECTIVE:We examined the relationship between cerebral gray matter (GM) volume and severity of delusions and hallucinations in adults with schizophrenia. METHOD:MRI scans in 43 patients with schizophrenia were acquired. Correlations were computed between GM volume and clinician ratings of hallucinations and delusions...

journal_title：Schizophrenia research

authors： Cascella NG,Gerner GJ,Fieldstone SC,Sawa A,Schretlen DJ

更新日期：2011-12-01 00:00:00